Influence of non-steroid alanti-inflammatory drug naproxen on the intestinal microflora in experiment
The effect of naproxen on microbiocenosis different departments of the intestine of white rats (N=20) after intragastric administration of the drug at a dose of 10 mg/kg. In in vitro experiments revealed that naproxen slightly depresses Staphylococcus aureus ATCC 25923 (F - 49), Candida albicans ATCC 885-653, and has no effect on Escherichia coli ATCC 25922. The use of naproxen possible to ascertain the activation of all groups studied microorganisms in the proximal gastrointestinal tract as compared with the intact group of animals. Established the presence of Escherichia in all departments of the intestine after administration of naproxen amid the lack Escherichia coli in duodenum of intact animals (experiment level (2,1 ± 0,20) lgKUO/g). Fixed also some activation of lactic acid bacteria in the upper part of the intestine: lactobacilli - at the level of (4,0 ± 0,16) lgKUO/g vs (3,4 ± 0,29) in the control and bifidobacteria at the level of (2,0 ± 0, 30) against (3,0 ± 0,28) lgKUO/g.