Structural and functional changes in endothelium inexperimental delayed type of hypersensitivity
The aim of the study was to examine the pathogenic mechanisms of endothelial dysfunction and to establish its role in the development of toxic and allergic process (delayed type hypersensitivity) in experimental model of mucosal lesions of the oral cavity. In an experimental model of the induction of DTH morphological changes were found, testifying the endothelial dysfunction in the development of toxic and allergic type of oral cavity mucosal lesions. This is confirmed by the nature of the morphological changes in the damaged area of the mucosa and endothelial dysfunction markers even in large vessels (aorta) in exposed animals. This have to be taken into account in medical treatment development.