Feature central hemodynamics, intracranial pressure and microcirculation in the capillaries cerebral cortex of rats with different hemorrhagic stroke subtypes on the background infusions of Ademol or nimodipine


  • N. V. Zhaboyedova
  • O. A. Khodakivskiy
  • I. L. Rokunets
Keywords: Ademol, nimodipine, hemorrhagic stroke, laser Doppler

Abstract

Coursework infusion in rats with model hemorrhagic stroke ampoule 1,0% solution of Ademol and the reference drug nimodipipin in doses respectively 2 mg/kg and 30 mkg/kg, falling amortized process of brain perfusion, stabilizing its performance in the microcirculation coefficient levels that exceeded similar to those in the control group pathology on average 3,99 and 2,76 times (intracerebral hemorrhage (ICH)) and 7,30 and 4,74 times, respectively, with subarachnoid hemorrhage (SAH), p<0.05. The magnitude of the stimulating effect on the microcirculation in the cortex adjacent to the middle cerebral artery, solution of Ademol significantly superior to nimodipine with ICH in an average of 1,44, while the SAC 1,54 times, respectively. The basis for the restoration of microcirculation and oxygenation in the blood vessels of the microvasculature of the brain against the background of the separate treatment of hemorrhagic stroke solutions of Ademol and nimodipine, is the stabilization of indicators reflecting the state of the central of hemodynamic and de-escalation of intracranial pressure.

Published
2017-03-31
How to Cite
Zhaboyedova, N. V., Khodakivskiy, O. A., & Rokunets, I. L. (2017). Feature central hemodynamics, intracranial pressure and microcirculation in the capillaries cerebral cortex of rats with different hemorrhagic stroke subtypes on the background infusions of Ademol or nimodipine. Biomedical and Biosocial Anthropology, (27), 62-66. Retrieved from https://bba-journal.com/index.php/journal/article/view/184

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