Oxidative stress in experimental renal homogenates during experimental burn disease and its correction by multifunctional infusion solutions
On the model of experimental burn disease in rats (development of area of defeat to 21-23 %) the state of oxidizing stress is studied in the tissues of the kidneys in the early terms of burn trauma on 1, 3 and 7 days. It is set that the primary products of peroxidation oxidization of lipids (POL) considerably increased in kidney tissue homogenates, especially at a correction only by 0,9% solution of NaCl: so, the increase of ketones increased almost in 3,5-5 times on the terms of supervision from 1th to the 7th day of experience. Application of pharmacological correction by lactoprotein with sorbitol (LPS) or НАЕS-LX 5% assisted the considerable decline of accumulation of primary products of POL activating, with a larger effect from НАЕS-LX 5%. A similar was a dynamics of afterproduct POL - МДА?, on a background of NaCl its level increased more than in 3-4 times, while both of solutions restrained this increase (only 115,5%-74, 1% from НАЕS-LX and 108,6%-65, 5% from LPS). Development of oxidizing stress associated with reduced activity of catalase in kidney tissues, both solutions diminished her deficit twice. Examinee solutions protected activity also of superoxide dismutase, promoting her in 1,8-2,7 times, but her complete normalization up to 7th day of research was not observed although. A maximal positive dynamics is educed for maintenance of activity of glutathione reductase, the level of tocopherol also grew in half. Obviously, that both solutions mediated protected kidney tissues from oxidizing stress at burn disease. Further researches can be continued in the clinical tests of НАЕS-LX 5% at burn disease.