Impact of benzogeksony on intraabdominal pressure in rats with acute pancreatitis
The goal of research was to investigate the effect of ganglionic blocker benzogeksony on intra-abdominal pressure (IAP) in rats with experimentally simulated acute pancreatitis (AP). Research of IAP in rats was carried out by an indirect method, which consisted in the measurement of pressure in the rectum using a latex container filled with liquid. Due to the small size container not irritate the wall of the rectum and did not stir motility, so the change in pressure in container corresponds to IAP, which was confirmed by our preliminary studies. It is found that in rats with AP induced by L-arginine, IAP was 4.5 times greater (p<0,001, n=10) than in healthy rats (intact control group, n=6). Benzogeksony (3.2 mg/kg) to 30,4% (p<0,001, n=10) reduced the IAP in rats with AP, indicating the effectiveness of ganglionic blockers in the treatment of intra-abdominal hypertension in patients with AP, which are in the intensive ward therapy.