State of vascular mobile endothelial function and structural changes of the vascular wall in patients with stage ІІ essential hypertension depending on the presence of concomitant nonalcoholic fatty liver disease
In order to identify and evaluate changes of a mobile vascular endothelial function and structural specifics of the vascular wall among patients with essential hypertension and concomitant nonalcoholic fatty liver disease 170 patients with stage II essential hypertension, 98 (57.6%) women and 72 (42.4%) men, average age 49.3 ± 0,5 y., were examined. Additional nonalcoholic steatohepatosis was registered in 109 (64.1%) patients, 61 (35.9%) patients had no signs of liver impression. In patients with concomitant steatohepatosis significantly 3th degree of hypertension was more frequently observed. Patients with stage II hypertension and concomitant "fatty" liver infiltration had some significant (p<0.05) differences compared with patients without steatohepatosis: decreased index of endothelial dysfunction, a higher incidence of atherosclerotic plaque registration and increased arterial stiffness index. Thus, the index of endothelial dysfunction and arterial stiffness, describing the initial functional and structural changes of the vessel wall, and increased frequency of atherosclerotic plaques detection may be considered as additional markers of overall cardiovascular risk in patients with second stage hypertension and concomitant nonalcoholic fatty liver disease.