Markers of neurodegeneration and behavioral responses in rats with hyperhomocysteinemia under modulation of hydrogen sulfide metabolism


  • P. A. Yurchenko
  • N. V. Zaichko
Keywords: homocysteine, hydrogen sulfide, brain, behavioral responses, aminooxyacetate, NaHS

Abstract

It was estimated the effect of hydrogen sulfide (H2S) metabolism modulators on brain-derived neurotrophic factor (BDNF) and neuron-specific enolase (NSE) serum and behavioral responses in the "open field" test in rats with HHC. HHC caused an increase of NSE serum level and decrease of BDNF serum level in rats. H2S synthase inhibitor enhance the HHC inhibition of oriented-experimental activity and vegetative balance in rats in the test "open field" and H2S donors have the opposite effect.

Published
2017-03-31
How to Cite
Yurchenko, P. A., & Zaichko, N. V. (2017). Markers of neurodegeneration and behavioral responses in rats with hyperhomocysteinemia under modulation of hydrogen sulfide metabolism. Biomedical and Biosocial Anthropology, (24), 78-82. Retrieved from https://bba-journal.com/index.php/journal/article/view/20