Features of metabolic changes of lipids in serum of blood in patients with polyps of intestine and stomach
Aim - examine and assess the metabolism of lipids by means determine the composition of fatty acids in the blood serum of patients with polyps in the intestines and stomach. We examined 35 (21,7%) healthy individuals (group І, comparison), 64 (39,8%) patients with intestinal polyps (ІІ group) and 62 (38,5%) patients with polyps of the stomach (group ІІІ). The fatty-acid composition of lipids in the blood serum was studied for patients with the intestinal and stomach polyps biochemical method on the gas-liquid chromatographic series of "Cvet - 500" within the isothermal mode. The quantitative estimation of composition of fatty-acid lipids in the blood serum was conducted after the method of setting of normal area by determination of peaks of methyl ethers of fatty-acid and their particles (in %). For patients with the intestinal and stomach polyps the fatty-acid composition of lipids is changed. This change is characterized by the increase of the amount of unsaturated fatty-acids (including polyunsaturated acids). This amount may grow up to (54,7 1,8) % and higher (р<0,001). At the same time the amount of saturated fatty-acids decreases to (45,3±1,8) % and lower (р<0,001). These changes in fatty- acid composition testify the deviation of lipid metabolism; healthy individuals have deviation of (43,0±2,0) % and (57,0±2,0) % correspondingly. Number of palmitic (C16:0) and stearic (C18:0) fatty acids in blood serum of patients with polyps of the stomach and the intestine is decreased to (28,6±1,5) and (5,8±0,6) % and less (р<0,001). Healthy individuals have deviation of (41,9±0,9) and (15,1±1,3) % correspondingly. When the number of polyps increases changes are more substantial. Research results have established the need for correction of fatty acids in the treatment of patients with polyps of the intestine and stomach.