Contemporary views at the problems of heart regeneration
Contemporary knowledges of genetic and epigenetic results while cells reprogramming, heart development and cardiomyocytes differentiation develops rapidly. Apoptosis of cardiomyocytes is the main process inpathogenesis of a number of heart diseases, including ischemic heart disease and heart failure. Ensuring the survival of heart cells through blocking apoptosis is an important strategy of improving heart functioning. The combination of rapid genome editing and highly effective chemical methods of heart cells differentiation enables to define the effectors of various stages of heart differentiation and cardiomyocytes proliferation.