Comparative analysis of the melatonin's effect at different dose range and of some cytoprotectors on the dynamic of rabbits' intraocular pressure in normal conditions and under contusion of the eye
In experiments on rabbits of the Chinchilla breed in conditions of eye contusion caused by the action of carbon dioxide under pressure established that the melatonin in a wide dose range (5-15 mg/kg intravenous) amortizes the lowering of IOP in eye contusion conditions, surpassing the effectiveness of referents drugs: citicoline, corvitin or thiotriazoline. In this case, as the drugs of comparison, melatonin does not affect the average values of IOP in its applying to animals without ophthalmic pathology. The ability of melatonin to amortize decreasing of intraocular pressure, that is pathognomonic for eye injury, is one of the leading mechanisms of its neuroprotective activity that may be associated with existing vasoactive effect. The obtained data form the basis for differentiated neuroretinoprotective therapy and, depending on the pathology, allow to choose one or the other drug to a certain conditionally effective dose.