Neyroretynoprote ctive effects of mexidol in conditions of temporary ischemia of the eye


  • I. L. Chereshnyuk
  • G. V. Zagoriy
  • O. A. Khodakovskiy
Keywords: Mexidol, neuroprotective effect, retina, ischemia-reperfusion of the eye

Abstract

In experimental conditions (60 minutes of total ischemia-reperfusion in rats` eyes) was found mexidol ability (100 mg/ kg intraperitoneally) to weaken the destruction of membranes of retinal neurons, which showed stabilization of serum markers that reflect the integrity of the membranes of neurons of the retina - the activity of neuron-specific enolase and level protein S 100. These results indicate the existence of the study drug neuroprotective activity, which is the basis for the preservation of the structural and functional integrity of the retina in a model of pathology. These data substantiate the feasibility of using mexidol as a reference drug in preclinical evaluation neuroprotective activity of biologically active compounds.

Published
2017-03-31
How to Cite
Chereshnyuk, I. L., Zagoriy, G. V., & Khodakovskiy, O. A. (2017). Neyroretynoprote ctive effects of mexidol in conditions of temporary ischemia of the eye. Biomedical and Biosocial Anthropology, (24), 90-92. Retrieved from https://bba-journal.com/index.php/journal/article/view/23