Influence of hypolipidemicagents on morphological changes in the liver of the rats with nonalcoholic fatty liver disease associated with hyper homocysteinemia


  • D. A. Nekrut
  • N. V. Zaichko
  • A. P. Korol
Keywords: Nonalcoholic fatty liver disease, hyperhomocysteinemia, steatosis, fibrosis, morphological studies

Abstract

Morphological study of liver of rats with a model of non-alcoholic fatty liver disease associated with hyperhomocysteinemia (NAFLD+HHС), reveals steatosis, fibrosis and inflammatory changes. The use of lipid-lowering agents (PUFA -3 and Simvastatin) provided a reduction in the number of hepatocytes with fatty degeneration of the cytoplasm, necrotic hepatocytes, and leukocyte infiltration in rats with NAFLD+HHС. The greater anti-steatogenic effect was manifested with the use of PUFA -3 than with Simvastatin, as evidenced by a reduced degree of steatosis of the liver (1.20±0.20 points against 2.20±0.20 points, p<0.05).

Published
2017-03-31
How to Cite
Nekrut, D. A., Zaichko, N. V., & Korol, A. P. (2017). Influence of hypolipidemicagents on morphological changes in the liver of the rats with nonalcoholic fatty liver disease associated with hyper homocysteinemia. Biomedical and Biosocial Anthropology, (28), 66-71. Retrieved from https://bba-journal.com/index.php/journal/article/view/233