Structural changes of rat's renal cortex in late period of skin burn injury under the conditions of the infusion by lactoprotein with sorbitol
The article presents and analyzes the results of the experimental investigation of structural changes of rat's renal cortex in late period of skin burn injury under the conditions of the infusion by lactoprotein with sorbitol. Infusion of lactoprotein with sorbitol cause the clearly expressed nephroprotective effects, but the renal cortex is characterized by the presence of morphological changes in components of glomerular and tubular apparatus. Mitoptosis play a main role in the adaptation of the number and quality of mitochondria in tubular epithelial cells to new microenvironmental conditions in situation of burn disease. We have often observed a mixed form mitoptosis in which mitochondria undergo condensation and degradation, followed by vesicular fragmentation of cristea, but (instead of disruption of the outer mitochondrial membrane) the mitochondria become engulfed in autophagolysosome (or transformed into autophagolysosome). Massive mitoptosis leading to autophagy can result in cell death. Thus, mitochondrial degradation and dysfunction are the good reasons for its elimination under the clear principle: "it is better to die than to be wrong". Specific influence of lactoprotein with sorbitol consists of manifestation of the first educed ultrastructural effect of high structuralisation of mitochondria in renal epithelialcells of rats with the burn of skin due to the increase of thickness and increase of electronic density of all of the tools of mitochondrial envelope. Such strengthening of mitochondrial envelope part of mitochondria has a regulator and safety device of massive mitoptosis.