Features of treatment of patients with chronic obstructive pulmonary disease with concomitant somatopsychic changes
To evaluate the clinical, functional and psychocorrecting efficiency to treatment of COPD patients with the inclusion of nootropic drug examined 37 patients with COPD using conventional in pulmonology practice techniques and made the definition of psychological status using standardized international questionnaires determine the level of neuroticism, anxiety and depression. We studied the dynamics of clinical symptoms, indicators of lung function and patients` somatopsychic characteristics background with carrying out of complex treatment that includes medication baseline (fluticasone propionate and salmeterol) in combination with the derivative of GABA - Phenibut a dose of 250 mg twice a day for a month. Comparison group consisted of 32 patients with COPD, representative by age, sex and severity of disease to the main, who received only basic therapy. Determined that patients on combined therapy regime characterized by significantly better dynamic indicators of control of the COPD (mean on a scale CAT increased by 30,0%, and on a scale mMRC - 10,3% of the original) and the level of bronchial obstruction (FEV1 increased on average by 5,3%). Also observed probable decrease of prevalence somatopsychic syndromes (neuroticism by 43,2% (p=0,006), state anxiety - by 62,2% (p=0,003), trait anxiety - by 46,0% (p=0,037) and depression - 24,3%) compared to the control group. Detected drug efficacy can recommend it for inclusion in schemes of complex therapy of patients with COPD.