Influence of the intestinal microbiota to the reproduction of enteroviruses in the experiment

  • V.V. Bobyr
  • V.A. Ponyatovsky
  • O.M. Dyuzhikova
  • O.A. Nazarchuk
  • V.B. Nastenko
  • V.P. Shirobokov
Keywords: antibiotics, dysbiosis, enteroviruses, infection, intestinal microflora.


The results of the study of the influence of bacterial microflora of the intestine on the duration of the preservation of enterovirus infectivity in in vivo and in vitro conditions are presented in this work. According to the results of the study, the ability of enteroviruses to maintain infectious activity in fecal masses of animals with preserved microflora and in conditions of antibiotic induced dysbiosis has been shown. The connection between the growth of virus titres in fecal masses of animals and the presence of microorganisms has been established. Increased viability of the polio virus of type 1 (Lsc2ab strain) has been shown during storage in the presence of bacteria. The presence of Bacillus subtilis and Lactobacillus plantarum has been established to the best contributing in maintaining the infectivity of viruses to 60 days. The scientific hypothesis about the possible antiviral effect of antibiotics on the background of formation of dysbiotic states has been formulated.


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How to Cite
Bobyr, V., Ponyatovsky, V., Dyuzhikova, O., Nazarchuk, O., Nastenko, V., & Shirobokov, V. (2017). Influence of the intestinal microbiota to the reproduction of enteroviruses in the experiment. Biomedical and Biosocial Anthropology, (29), 10-15. Retrieved from