Structural changes of rats’ aggregated lymphoid nodules of ileum in an experimental skin burn injury under the conditions of infusion by Gekoton


  • R.M. Matkivska
Keywords: skin burn injury, infusion therapy, Gekoton, structural changes, aggregated lymphoid nodules.

Abstract

With the help of light and electron microscopy, it has been established that the general manifestation of structural changes in the accumulated lymphoid nodules of the ileum (Peyer's patches) of rats with experimental thermal trauma of the skin is necrosis and apoptosis of functionally different cells, which take place on the background of distinct changes in the hemo- and lymphomicrocirculation bed.

We have established phase changes of accumulated lymphoid nodules of the ileum of heated rats, whose vessels provide the possibility of performing the necessary immune function of recirculation and transmural migration of immune-competent cells. It has been determined that skin burn induces necrosis and/or apoptosis of lymphocytes, as well as cells of the follicular-associated epithelium and antigen-presenting cells of congested lymphoid nodes. Compensation for marked altered manifestations occurs not only by protecting cells against damages that result in cell death, or by increasing the proliferation of intact cells (for example, expressive lymphocyte mitosis in the lymphoid nodal hermetic center), but also by involving additional mechanisms that have change the conditions and rate of recirculation of immunocompetent cells. The obtained results testify to the integral reaction of the immune system to burn, which can be optimized and stabilized in a timely and adequate infusion therapy with the use of Gekoton.

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Published
2017-10-27
How to Cite
Matkivska, R. (2017). Structural changes of rats’ aggregated lymphoid nodules of ileum in an experimental skin burn injury under the conditions of infusion by Gekoton. Biomedical and Biosocial Anthropology, (29), 20-26. Retrieved from https://bba-journal.com/index.php/journal/article/view/278