Comparative study of histological changes of bone tissue of the mandible of rats in the area of traumatic defect in pathology of hepatobiliary system


  • S.S. Polischuk
  • I.S. Davydenko
  • S.M. Shuvalov
Keywords: rat, maxillofacial area, perforation defect of mandible, regeneration, morphometric analysis.

Abstract

Experiment was conducted on 60 white male rats. Animals were in the general diet, had free access to water and food. In the process of work, the rats were divided into 3 groups: control - 20 rats - study of histological changes of bone tissue of the mandible of healthy rats with trauma of the mandible at the site of defect; experimental number 1 - 20 rats, the study of histological changes of bone tissue of the mandible of rats with trauma of the mandible at the site of defect in obstructive hepatitis, received by ligation and intersection of the total bile duct; experimental number 2 - 20 rats - study of histological changes of the mandibular bone tissue of rats with trauma of the mandible at the site of the defect in toxic hepatitis, obtained by introducing per os four carbon monoxide. All rats injured the lower jaw through perforation and defect formation. In the future, the histological signs of healing of the area of the perforation defect were observed.

In the experimental pathology of the hepatobiliary system regeneration of the defect site of the mandible worsens, which is manifested by a decrease in the rate of recovery of the specific volume (%) of fibrotic reticular tissue in 2.6 times in obstructive hepatitis and toxic hepatitis - 3.4 times. In the experimental liver disease, osteo regeneration of the defect of the mandible is slowed down. In patients with trauma of the mandible, when detecting the pathology of the hepatobiliary system, it is advisable to perform correction of metabolic processes.

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Published
2017-10-27
How to Cite
Polischuk, S., Davydenko, I., & Shuvalov, S. (2017). Comparative study of histological changes of bone tissue of the mandible of rats in the area of traumatic defect in pathology of hepatobiliary system. Biomedical and Biosocial Anthropology, (29), 66-73. Retrieved from https://bba-journal.com/index.php/journal/article/view/288