Influence of amantadine hydrochloride on the activity of apoptotic and proliferative processes in the lower alveolar nerve of rabbits with its iatrogenic compression-toxic lesion with differentiated filling of the materials "Foredent" and "AH-plus"


  • A.V. Pogorila
  • М.М. Shinkaruk-Dykovytska
  • A.A. Khodakovsky
  • I.L. Chereshnyuk
Keywords: amantadine hydrochloride, apoptosis, neuroprotection, iatrogenic compression-toxic lesion of the lower alveolar nerve.

Abstract

Using the method of protocol-cytometric analysis, the fact of activation of apoptosis and proliferation among the cells of the Gasserum node was established with a preliminary 30-day interaction of the Foredent or AH-Plus pastes with the mandibular nerve. Such destructive-degenerative changes were verified by the growth of a pool of cells whose nuclear DNA was in the period of Sub-G0G1 (apoptosis) and the synthetic phase S (proliferation). The most described phenomena were noted when inserting a Foredent filling solution into the trepanation hole, p <0.05. The absence of neuronal compression and toxic effects, of each of the pastes undergoing bone-plastic trepanation of the mandibular nerve, in no way changed the ratio of cells in different phases of the cell cycle in the cytometric suspension from the Gasser node, p <0.05. Therapeutic intragastric daily, during 30 days of iatrogenic compression-toxic affection of the lower alveolar nerve of rabbits using the drug amantadine sulfate at a dose of 10 mg/kg exhibits neurocytoprotective effect on the cells of the trigeminal node.

References

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Published
2017-10-27
How to Cite
Pogorila, A., Shinkaruk-DykovytskaМ., Khodakovsky, A., & Chereshnyuk, I. (2017). Influence of amantadine hydrochloride on the activity of apoptotic and proliferative processes in the lower alveolar nerve of rabbits with its iatrogenic compression-toxic lesion with differentiated filling of the materials "Foredent" and "AH-plus&quot;. Biomedical and Biosocial Anthropology, (29), 100-104. Retrieved from https://bba-journal.com/index.php/journal/article/view/294