The role of osteopontin in the development of liver fibrosis in children with chronic viral hepatitis B

  • I.I. Nezgoda
  • L.V. Moroz
  • S. Singh
  • O.O. Singh
Keywords: chronic hepatitis B, children, lymphoblastic leukemia, fibrosis, osteopontin.


The aim of this study was to determine the plasma osteopontin (OPN) level in chronic viral hepatitis B (CHB) children with acute lymphoblastic leukemia (ALL), depending on sex, age, viral load, degree of fibrosis and inflammatory activity in the liver. Were studied 71 children with CHB aged 3 to 17 years, including 41 CHB patients with ALL (main group) and the control group consisted of 20 healthy children. The verification of the CHB diagnosis was performed on the basis of HBV-DNA detection in the blood of patients using PCR technique and ELISA for HBsAg, HBeAg, anti-HBsAg, anti-HBcAg, anti-HBeAg. The degree of fibrosis was determined on the METAVIR scale using Fibrotest. The level of OPN in serum was determined by ELISA. According to results, the level of this glycopeptide in CHB children with ALL is significantly higher than in patients with CHB and healthy individuals (p<0.05). Irrespective of gender, age, and viral load, significantly higher values of OPN were detected in CHB children with ALL than in the rest of the individuals. Many children of the main group have been diagnosed with fibrosis (F1-F3) with different inflammatory activity process in the liver (A0-A3). In CHB patients with ALL, the level of plasma OPN positively correlates with the degree of fibrosis and inflammatory activity in the liver (p<0.05). Osteopontin claims to be a new non-invasive biomarker of liver fibrosis.


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How to Cite
Nezgoda, I., Moroz, L., Singh, S., & Singh, O. (2017). The role of osteopontin in the development of liver fibrosis in children with chronic viral hepatitis B. Biomedical and Biosocial Anthropology, (29), 154-160. Retrieved from