Quality of life of patients with cancer of the esophagus and cardioesophageal cancer


  • A. S. Klimas GA “O.O. Shalimov National Institute of Surgery and Transplantology, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
Keywords: quality of life, EORTC QLQ-C30 V.3 questionnaire, EORTC QLQ-OG25 questionnaire, esophageal cancer, cardioesophageal cancer, proximal gastrectomy with esophageal resection, Lewis or Osawa-Garlock accesses, esophagogastroanastomosis

Abstract

The urgency of the study is due to the aggressiveness of esophageal cancer and cardioesophageal cancer, low survival rate of patients, the need for further development aimed at improving the consequences of surgical intervention, the effectiveness of which can be evaluated with the help of determining the quality of life of these patients. The aim of the work is to assess the quality of life of patients with esophagus cancer and cardioesophageal cancer after radical surgery, depending on the variant of the formed esophagogastroanastomosis based on the analysis of indicators of the general condition of patients and the severity of esophageal-gastric symptoms at different stages of observation. 60 patients with cancer of the esophagus and cardioesophageal cancer after proximal gastrectomy with resection of the esophagus accesses of Lewis or Osawa Garlock were subject to questioning. The patients were divided into two groups: the study group consisted of 30 patients who had developed the mechanical invagination of the esophagogastro-anastomosis developed and protected by the Ukrainian patent, the comparison group made up 30 patients who had the end-to-side mechanical esophagogastroanastomosis formed. Quality of life was assessed before surgery and at 3, 6, and 12 months after surgery. The EORTC QLQ-C30 V.3 questionnaire was used to assess the general condition of the patients, and the EORTC QLQ-OG25 questionnaire was used to assess the presence of specific gastrointestinal symptoms. Statistical analyses were performed using EZR v.1.35 software (Saitama Medical Center, Jichi Medical University, Saitama, Japan, 2017), which is a graphical user interface for R (The R Foundation for Statistical Computing, Vienna, Austria). To analyze the dynamics of the indicators, the Friedman criterion was used for repeated measurements, pairwise comparisons were performed according to the Conover criterion. To verify the validity of the differences between dependent samples, the non-parametric W-criterion of Wilcoxon was used. It was established that the general condition of the patients after surgery, assessed by the EORTC QLQ-C30 V.3 scales, did not depend on the method of formation of esophagogastroanastomosis. The results of the study of the quality of life of patients after surgery with various ways of forming esophagogastroanastomosis modulo EORTC QLQ-OG25 showed significantly lower frequency rate of symptoms such as reflux, pain and discomfort in the stomach, nutritional problems in front of other people and a sense of physical unattractiveness in the group of patients for which formation of a mechanical invagination esophagogastroanastomosis was applied.

References

[1] Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J. … de Haes, J. C. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J. Natl. Cancer Inst., 85(5), 365-376. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/8433390

[2] Ajani, J. A., Barthel, J. S., Bentrem, D. J., D'Amico, T. A., Das, P., Denlinger, C. S. … Wright, C. D. (2011). Esophageal and Esophagogastric junction cancer. J. Natl. Compr. Canc. Netw., 9, 830-887. doi: 10.6004/jnccn.2011.0072

[3] Conover, W. J. (1999). Practical Nonparametric Statistics. (3rd Ed.). New York: Wiley & Sons. ISBN-13: 978-0471160687, ISBN-10: 9780471160687

[4] Conyro, T., Marchal, F., & Blazeby, J. M. (2006). Quality of life in patients with oesophageal and gastric cancer: an overview. Oncology, 70, 391-402. Retrieved from http://dx.doi.org/10.1159/000099034

[5] Courrech Staal, E. F., van Sandick, J. W., van Tinteren, H., Cats, A., & Aaronson, N. K. (2010). Health-related quality of life in long-term esophageal cancer survivors after potentially curative treatment. J. Thorac. Cardiovasc. Surg., 140, 777-783. https://doi.org/10.1016/j.jtcvs.2010.05.018

[6] Djarv, T., & Lagergren, P. (2011). Six-month postoperative quality of life predicts long-term survival after oesophageal cancer surgery. Eur. J. Cancer, 47, 530-535. doi: 10.1016/j.ejca.2010.10.014

[7] Djärv, T., & Lagergren, P. (2012). Quality of life after esophagectomy for cancer. Expert Review of Gastroenterology & Hepatology, 6(1), 115-122. https://doi.org/10.1586/egh.11.91

[8] Djarv, T., Lagergren, J., Blazeby, J. M., & Lagergren, P. (2008). Long-term health-related quality of life following surgery for oesophageal cancer. Br. J. Surg., 95, 1121-1126. Retrieved from http://dx.doi.org/10.1002/bjs.6293

[9] Dorcaratto, D., Grande, L., Ramón, J. M., & Pera, M. (2011). Calidad de vida en pacientes con cáncer de esófago y de estómago [Quality of Life of Patients With Cancer of the Oesophagus and Stomach]. Cirugia Espanola, 89, 635-644.

[10] Fayers, P. M., Aaronson, N. K., Bjordal, K., Groenvold, M., Curran, D., & Bottomley, A. (2001). The EORTC QLQ-C30 Scoring Manual. (3rd ed.). Brussels, Belgium: European Organization for Research and Treatment of Cancer. ISBN (Print) 2-93006416-1. Retrieved from https://www.eortc.be/qol/files/SCManualQLQ-C30.pdf

[11] Fernandez, F. G., & Meyers, B. F. (2004). Quality of life after esophagectomy. Semin. Thorac. Cardiovasc. Surg., 16(2), 152-159. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/15197690

[12] Gur'yanov, V.G., Lyakh, Yu.E., Pariy, V.D., Short, O.V., Chaly, O.V., Chalyi, K.O., & Tsekhmyster, Ya.V. (2018). Biostatistics guide. Analysis of the results of medical research in the EZR package (R-statistics): tutorial. К.: Vistka.

[13] Hitz, F., Ribi, K., Li, Q., Klingbiel, D., Cerny, T., & Koeberle, D. (2013). Predictors of satisfaction with treatment decision, decision-making preferences, and main treatment goals in patients with advanced cancer. Supportive Care in Cancer, 21(11), 3085-3093. doi: 10.1007/s00520-013-1886-4

[14] Lagergren, J., Smyth, E., Cunningham, D., & Lagergren, P. (2017). Oesophageal cancer. Lancet., 390, 2383-2396. doi: 10.1016/S0140-6736(17)31462-9

[15] Lagergren, P., Avery, K. N., Hughes, R., Barham, C. P., Alderson, D., & Falk, S. J. (2007). Health-related quality of life among patients cured by surgery for esophageal cancer. Cancer, 110, 686-693. Retrieved from http://dx.doi.org/10.1002/cncr.22833

[16] Lagergren, P., Fayers, P., Conroy, T., Stein, H. J., Sezer, O., Hardwick, R. … Blazeby, J. M. (2007). Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-OG25, to assess health-related quality of life in patients with cancer of the oesophagus, the oesophago-gastric junction and the stomach. Eur. J. Cancer., 43(14), 2066-2073. doi: 10.1016/j.ejca.2007.07.005

[17] Parameswaran, R., McNair, A., Avery, K. N., Berrisford, R. G., Wajed, S. A., & Sprangers, M. A. (2008). The role of health-related quality of life outcomes in clinical decision making in surgery for esophageal cancer: a systematic review. Ann. Surg. Oncol., 15, 2372-2379. doi: 10.1245/s10434-008-0042-8

[18] Scarpa, M., Valente, S., Alfieri, R., Cagol, M., Diamantis, G., Ancona, E., & Castoro C. (2011). Systematic review of health-related quality of life after esophagectomy for esophageal cancer. World J. Gastroenterol., 17(42), 4660-4674. doi: 10.3748/wjg.v17.i42.4660

[19] Schandl, A., Lagergren, J., Johar, A., & Lagergren, P. (2016). Health-related quality of life 10 years after oesophageal cancer surgery. Eur. Journal of Cancer, 69, 43-50.

[20] Thrumurthy, S. G., Morris, J.J.A., Mughal, M. M., & Ward, J. B. (2011). Discrete-choice preference comparison between patients and doctors for the surgical management of oesophagogastric cancer. British Journal of Surgery, 98(8), 1124-1131. doi: 10.1002/bjs.7537

[21] Tomaszewski, K. A., Püsküllüoğlu, M., Biesiada K., Bochenek J., Ochenduszko, S., Tomaszewska, I. M. … Krzemieniecki, K. (2013). Main influencing factors and health-related quality of life issues in patients with oesophago-gastric cancer – as measured by EORTC tools. Contemp. Oncol. (Pozn), 17(3), 311-316. doi: 10.5114/wo.2013.35280

[22] Usenko, O. Yu., Sidyuk, A. V., & Klimas, A. S. (2016). Method of performing esophagectomy. Patent of Ukraine №107325, IPC: A61B 17/00 A61B 17/115 . Kyiv: State Patent Office.

[23] van den Boorn, H. G., Engelhardt, E. G., van Kleef, J., Sprangers, M.A.G., van Oijen, M.G.H., Abu-Hanna, A. … van Laarhoven, H.W.M. (2018). Prediction models for patients with esophageal or gastric cancer: A systematic review and meta-analysis. PLoS One, 13(2), e0192310. doi: 10.1371/journal.pone.0192310
Published
2018-06-20
How to Cite
Klimas, A. S. (2018). Quality of life of patients with cancer of the esophagus and cardioesophageal cancer. Biomedical and Biosocial Anthropology, (31), 18-28. https://doi.org/https://doi.org/10.31393/bba31-2018-03