Age and gender features of thigh rheogram indicators in practically healthy adolescents

  • L. L. Hmel National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • О. А. Serebrennikova National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • Yu. V. Kyrychenko National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • V. O. Gnenna National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Keywords: thigh rheogram indicators, practically healthy adolescents, age, gender


According to many studies, the rheovasographic index of the thighs can detect slight changes in the vessels, do not constitute a critical inconvenience, but in advance indicate that more serious diseases of the lower limb are approaching. The purpose of the study is to determine the age and gender features of thigh rheogram indicators in practically healthy adolescents in the Podillia region of Ukraine. The rheographic parameters of the thighs of 103 practically healthy boys aged from 13 to 16 years old and 108 girls aged from 12 to 15 years, urban residents of the Podillia region of Ukraine, were determined using a cardiology computer diagnostic complex. The statistical processing of the obtained results was carried out in the license package “Statistica 5.5” using parametric and nonparametric methods for evaluating the obtained results. In 12-year-old girls, in comparison with other age groups, it was found that most of the amplitude indices (with the exception of the incisura amplitude), the time of the downstream part of the rheogram and the average speed of fast and slow blood flow are significantly higher, while the time of the rising part of the rheogram and fast and slow blood overflow and thumb vascular tone rates in most cases are significantly lower. In most cases, 13 and 14-year-old boys, compared to 15 and 16-year-old adolescents, the basic impedance and amplitude of the systolic wave, as well as most vascular tone rates and average slow-blood flow rates are significantly higher or tend to be higher. It has also been found that most of the time indicators (with the exception of slow blood flow time) in 14-year-old boys are significantly lower or tend to be lower than in other age groups of boys. When comparing rheogram data between boys and girls according to the calendar and biological age, the majority of amplitude and derivative indices, as well as the time of slow blood filling in 14 and 15-year-old girls, are significantly higher in girls. Boys have significantly higher values of the duration of the cardiac cycle and the time of the downstream part of the thigh rheogram, as well as all time and most indicators of vascular tone in 13-year-old boys than in 12-year-old girls. Thus, the expressed age and gender differences in the rheogram data of the thigh in practically healthy adolescents have been established.


[1] Ahti, T. M., Makivaara, L. A., Luukkaala, T., Hakama, M., & Laurikka, J. O. (2009). Effect of family history on the incidence of varicose veins: a population-based follow-up study in Finland. Angiology, 60(4), 487-491. doi: 10.1177/0003319709335510

[2] Antle, D. M., Cormier, L., Findlay, M., Miller, L. L., & Côté, J. N. (2018). Lower limb blood flow and mean arterial pressure during standing and seated work: Implications for workplace posture recommendations. Prev. Med. Rep., 10, 117-122. doi:

[3] Antle, D. M., Vézina, N., & Côté, J. N. (2015). Comparing standing posture and use of a sit-stand stool: analysis of vascular, muscular and discomfort outcomes during simulated industrial work. Int. J. Ind. Ergon., 45, 98-106. doi:

[4] Apikina, T. A., Zefirov, T. L.., Rusinova, S. I., Sitdikov, F. G., Bilalova, G. A., Dikopolskaya, N. B., … Zverev, A. A. (2013). Age anatomy, physiology and hygiene: a training manual. Kazan, KFU.

[5] Azhim, А., Akioka, K., Akutagawa, M., Hirao, Y., Yoshizaki, K., Obara, S., … Kinouchi, Y. (2007). Effect of gender on blood flow velocities and blood pressure: role of body weight and height. Conf. Proc. IEEE Eng. Med. Biol. Soc., 2007, 967-970. doi: 10.1109/IEMBS.2007.4352453

[6] Breitling, L. P. (2013). Current genetics and epigenetics of smoking/tobacco-related cardiovascular disease. Arterioscler. Thromb. Vasc. Biol., 33(7), 1468-1472. doi: 10.1161/ATVBAHA.112.300157

[7] Buryak, V. N, & Mahmutov, V. N. (2011). Features of vascular tone in children with arterial hypotension. Modern Pediatrics, 1, 89-91.

[8] Chang, P. N. K., Olin, J. W., Cooke, J. P., & Leeper, N. J. (2014). Clinical and socioeconomic factors associated with unrecognized peripheral artery disease. Vasc. Med., 19(4), 289-296. doi: 10.1177/1358863X14535475

[9] Dilenyan, L. P., Bagriy, A. S., Dilenyan, L. P., Belkaniya, G. S., Bagriy, A. S., Korepanov, S. K., … Puhalskaya, L. G. (2015). Anthropophysiological characteristics of the "hemodynamic model" of the age dynamics of blood circulation in humans. Modern problems of science and education, 2(2), 26-34.

[10] Fiebig, A., Krusche, P., Wolf, A., Krawczak, M., Timm, B., Nikolaus, S., … Schreiber, S. (2010). Heritability of chronic venous disease. Hum. Genet., 127(6), 669-674. doi: 10.1007/s00439-010-0812-9

[11] Fowkes, F. G., Rudan, D., Rudan, I., Aboyans, V., Denenberg, J. O., McDermott, M. M., … Criqui, M. H. (2013). Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis. Lancet, 382, 1329-1340. doi:

[12] Fronek, A., Criqui, M. H., Denenberg, J., & Langer, R. D. (2001). Common femoral vein dimensions and hemodynamics including Valsalva response as a function of sex, age, and ethnicity in a population study. Journal of vascular surgery, 33(5), 1050-1056. doi: 10.1067/mva.2001.113496

[13] Hirsch, A. T., Hartman, L., Town, R. J., & Virnig, B. A. (2008). National health care costs of peripheral arterial disease in the Medicare population. Vasc. Med., 13(3), 209-215. doi: 10.1177/1358863X08089277

[14] Kapilevich, L. V., Kabachkova, A. V., & Dyakova, E. Yu. (2009). Age morphology: Tutorial. Tomsk: Tomsk State University.

[15] Karol, S., & Robertson, M. M. (2015). Implications of sit-stand and active workstations to counteract the adverse effects of sedentary work: a comprehensive review. Work, 52(2), 255-267. doi: 10.3233/WOR-152168

[16] Komarova, L. N., Ryakhin, R. N., Aliev, F. S., & Zvezda, S. A. (2018). Ten-year results of varicose veins treatment. The Russian Archives of Internal Medicine, 3, 215-218.

[17] Kullo, I. J., & Leeper, N. J. (2015). The Genetic Basis of Peripheral Arterial Disease: Current Knowledge, Challenges and Future Directions. Circ. Res., 116(9), 1551-1560. doi: 10.1161/CIRCRESAHA.116.303518

[18] Leeper, N. J., Kullo, I. J., & Cooke, J. P. (2012). Genetics of peripheral artery disease. Circulation, 125(25), 3220-3228. doi: 10.1161/CIRCULATIONAHA.111.033878

[19] Lu, J. T., & Creager, M. A. (2004). The Relationship of Cigarette Smoking to Peripheral Arterial Disease. Reviews in cardiovascular medicine, 5(4), 189-193. PMID: 15580157

[20] Matouk, C. C., & Marsden, P. A. (2008). Epigenetic regulation of vascular endothelial gene expression. Circ. Res., 102(8), 873-887. doi: 10.1161/CIRCRESAHA.107.171025

[21] Messing, K., Tissot, F., & Stock, S. R. (2008). Distal lower-extremity pain and work postures in the Quebec population. Am. J. Public. Health., 98(4), 705-713. doi: 10.2105/AJPH.2006.099317

[22] Nicolaides, A. N., Kakkos, S., Baekgaard, N., Comerota, A., de Maeseneer, M., Eklof, B., … Perrin, M. (2018). Management of chronic venous disorders of the lower limbs. Guidelines according to scientific evidence. Part I. Int. Angiol., 37(3), 181-254. doi: 10.23736/S0392-9590.18.03999-8

[23] Olson, T. P., Schmitz, K. H., Leon, A. S., & Dengel, D. R. (2006). Vascular structure and function in women: relationship with body mass index. American journal of preventive medicine, 30(6), 487-492. doi: 10.1016/j.amepre.2006.02.006

[24] Ovcharenko, D. V., Kaputin, M. Yu. Voronkov A. A., & Platonov, S. A. (2012). Angiographic study of the anatomical variability of the arteries of the shin and foot. Angiology and Vascular Surgery, 18(1), 57-60.

[25] Proctor, D. N., Le, K. U., & Ridout, S. J. (2005). Age and regional specificity of peak limb vascular conductance in men. Journal of Applied Physiology, 98(1), 193-202. doi: 10.1152/japplphysiol.00704.2004

[26] Ridout, S. J., Parker, В. А., & Proctor, D. N. (2005). Age and regional specificity of peak limb vascular conductance in women. Journal of Applied Physiology, 99(6), 2067-2074. doi: 10.1152/japplphysiol.00825.2005

[27] Sandoo, A., Veldhuijzen van Zanten, J. J. C. S., Metsios, G. S., Carroll, D., & Kitas, G. D. (2010). The Endothelium and Its Role in Regulating Vascular Tone. Open Cardiovasc Med. J., 4, 302-312. doi: 10.2174/1874192401004010302

[28] Shvalb, P. G., & Uhov, Yu. I. (2009). Pathology of venous return from the lower extremities. Ryazan: «Tigel».

[29] Tabatabaeifar, S., Frost, P., Andersen, J. H., Jensen, L. D., Thomsen, J. F., & Svendsen, S. W. (2015). Varicose veins in the lower extremities in relation to occupational mechanical exposures: a longitudinal study. Occup. Environ. Med., 72(5), 330-337. doi: 10.1136/oemed-2014-102495

[30] Tsvyntarnyi, A. V., & Vadzuk, S. N. (2014). Features of the derivative indices of the rheogram of the thigh in healthy boys and girls of all ages. Bulletin of scientific research, 1(74), 37-39.

[31] Vadzuk, S. N., & Tsvyntarnyi, A. V. (2015). Age features of time and amplitude rheogram data of the thigh in healthy urban boys and girls. Bulletin of scientific research, 1(78), 20-22.

[32] Valdez, R., Yoon, P. W., Qureshi, N., Green, R. F., & Khoury, M. J. (2010). Family History in Public Health Practice: A Genomic Tool for Disease Prevention and Health Promotion. Ann. Rev. of Publ. Health., 31, 69-87. doi: 10.1146/annurev.publhealth.012809.103621

[33] Vebyakova, N. A., Fadeeva, N. A., & Feliksova, O. M. (2013). Gender features of hemodynamic reactions to loading. Basic research, 5(1), 33-37.

[34] Vereskun, Z. F., & Vereskun, S. B. (2011). The place of rheography in the clinical diagnosis of vascular pathology. New medicine of the millennium, 1, 56-58.

[35] Vysochanskyi, O. V. (2015). Sexual peculiarities of the relationships of indices of rheovasogram with anthropo-somatotypological parameters in healthy teens of mesomorphic somatotype. Abstracts are presented in the materials of the international scientific and practical conference “Medical science and practice: topical issues of interaction”, (Kyiv, pp. 60-63). Kyiv: Kiev Medical Scientific Center.

[36] Zelinsky, B. O., Zlepko, S. M., Kostenko, M. P., & Kovalchuk, B. M. (2000). Portable multifunctional device for diagnosing the vascular bed of the circulatory system. Measuring and computing engineering in technological processes, 1, 125-132.
How to Cite
Hmel, L. L., SerebrennikovaО. А., Kyrychenko, Y. V., & Gnenna, V. O. (2018). Age and gender features of thigh rheogram indicators in practically healthy adolescents. Biomedical and Biosocial Anthropology, (32), 73-79.

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