Features of the hormonal background of women with infertility on the background of endometriosis and methods of their correction

  • I. I. Kulyk Ivan Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
  • S. V. Khmil Ivan Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Keywords: infertility, endometriosis, hormones, sclerotherapy, inositol, vitamin D3, effect.


Endometriosis-associated infertility is characterized by a number of specific features that must be considered when choosing treatment methods. In each case, treatment should be individual, taking into account all clinical factors, as well as the impact of the disease and the effect of treatment on the quality of woman’s life. Objective – to analyze the concentration of the reproductive system hormones in women with endometriosis-associated infertility before and after sclerotherapy using pregravidary preparation with a complex vitamin medication with inositol and vitamin D3. The study included 70 women aged 21-40 years with endometriosis-associated infertility. The comparison group included 30 women with tuboperitoneal infertility factor. Determination of the concentration of the reproductive system hormones was performed in an accredited laboratory of the “Professor S. Khmil Clinic Medical Center” with the help of “Diagnostic Systems Laboratories, Inc.” test system (USA) using the analyzer “StatFax”. The medicament FT 500 plus was prescribed in a dosage of 1 sachet – once a day from the 2nd or 3rd day of the cycle during 2 menstrual cycles (cycle in which sclerotherapy was performed and subsequent cycle) for 1 group. Vitamin D3 was prescribed in prophylactic doses of 2.000 IU to women who were not diagnosed with a deficiency of this vitamin and in medium therapeutic doses for hypovitaminosis during 2 menstrual cycles. The sclerotherapy procedure was performed in a sterile operating room on the 6th – 8th day of the menstrual cycle by transvaginal puncture of the cyst and aspiration of its contents under the control of transvaginal ultrasound, introduction into the cyst capsule 95 % ethanol solution. Women with endometriosis-associated infertility, who were prescribed pregravidary preparation with a complex vitamin medication with inositol and vitamin D3 and sclerotherapy had probably lower levels of AMH (by 12.90 %), progesterone (by 9.84 %) and probably higher levels of FSH (by 14.47 %), LH (by 21.14 %) estradiol (by 35.55 %) relative to the comparison group. At the same time, significantly lower indicators of FSH (by 21.98 %), LH (by 32.89 %) and estradiol (by 32.23 %) were found against their values before sclerotherapy. Performing of sclerotherapy with pregravidary preparation with a complex vitamin medication with inositol and vitamin D3 to women with endometriosis-associated infertility has a positive effect on the hormonal background.


[1] Abbas, S., Ihle, P., Köster, I., & Schubert, I. (2012). Prevalence and incidence of diagnosed endometriosis and risk of endometriosis in patients with endometriosis-related symptoms: findings from a statutory health insurance-based cohort in Germany. European Journal of Obstetrics & Gynecology and Reproductive Biology, 160(1), 79-83. doi: 10.1016/j.ejogrb.2011.09.041
[2] Aflatoonian, A., Rahmani, E., & Rahsepar, M. (2013). Assessing the efficacy of aspiration and ethanol injection in recurrent endometrioma before IVF cycle: A randomized clinical trial. Iranian journal of reproductive medicine, 11(3), 179-184. PMID: 24639744
[3] Alborzi, S., Namavar Jahromi, B., & Ahmadbeigi, M. (2018). Recovery Rate of Patients with Recurrent Ovarian Endometriomas Using Sclerotherapy with 95% Ethanol. Journal of Obstetrics, Gynecology and Cancer Research (JOGCR), 3(3), 105-110.
[4] André, G. M., Vilarino, F. L., Christofolini, D. M., Bianco, B., & Barbosa, C. P. (2011). Aspiration and ethanol sclerotherapy to treat recurrent ovarian endometriomas prior to in vitro fertilization – a pilot study. Einstein (Sao Paulo), 9(4), 494-498. doi: 10.1590/S1679-45082011AO2081
[5] Augoulea, A., Mastorakos, G., Lambrinoudaki, I., Christodoulakos, G., & Creatsas, G. (2009). The role of the oxidative-stress in the endometriosis-related infertility. Gynecological Endocrinology, 25(2), 75-81. doi: 10.1080/09513590802485012
[6] Borham, M. (2014). Comparison between omentoplasty and partial cystectomy and drainage (PCD) techenques in surgical management of hydatid cysts liver in endemic area (Yemen). Journal of the Egyptian Society of Parasitology, 44(1), 145-150. doi: 10.12816/0006454
[7] Fisch, J. D., & Sher, G. (2004). Sclerotherapy with 5% tetracycline is a simple alternative to potentially complex surgical treatment of ovarian endometriomas before in vitro fertilization. Fertility and sterility, 82(2), 437-441. doi: 10.1016/j.fertnstert.2004.01.031
[8] Gatta, G., Parlato, V., Di Grezia, G., Porto, A., Cappabianca, S., Grassi, R., & Rotondo, A. (2010). Ultrasound-guided aspiration and ethanol sclerotherapy for treating endometrial cysts. La radiologia medica, 115(8), 1330-1339. doi: 10.1007/s11547-010-0586-0
[9] Giudice, L. C. (2010). Endometriosis. New England Journal of Medicine, 362(25), 2389-2398. doi: 10.1016/S0140-6736(04)17403-5
[10] Khamoshina, M. B., Vakhabova, M. I., & Kalinina, E. A. (2013). Медикаментозная терапия эндометриоза: возможности и перспективы [Endometriosis drug therapy: opportunities and prospects]. Медицинский совет – Medical advice, (8), 23-27.
[11] Khmil, S. V., Kulyk, I. I., & Mykula, R. P. (2018). Антиоксидантна терапія у жінок із безпліддям на фоні ендометріозу [Antioxidant therapy in women with infertility on the background of endometriosis]. Вісник соціальної гігієни та організації охорони здоров'я України – Bulletin of social hygiene and health care organization of Ukraine, 4(78), 56-63. doi: 10.11603/1681-2786.2017.4.8663
[12] Matsuzaki, S., Houlle, C., Darcha, C., Pouly, J. L., Mage, G., & Canis, M. (2009). Analysis of risk factors for the removal of normal ovarian tissue during laparoscopic cystectomy for ovarian endometriosis. Human reproduction, 24(6), 1402-1406. doi: 10.1093/humrep/dep043
[13] Miquel, L., Preaubert, L., Gnisci, A., Netter, A., Courbiere, B., Agostini, A., & Pivano, A. (2021). Transvaginal ethanol sclerotherapy for an endometrioma in 10 steps. Fertility and Sterility, 115(1), 259-260. doi: 10.1016/j.fertnstert.2020.08.1422
[14] Rubod, C., & Yazbeck, C. (2018). Surgical management of endometrioma: Different alternatives in term of pain, fertility and recurrence. CNGOF-HAS Endometriosis Guidelines. Gynecologie, obstetrique, fertilite & senologie, 46(3), 278-289. doi: 10.1016/j.gofs.2018.02.013
[15] Shakiba, K., Bena, J. F., McGill, K. M., Minger, J., & Falcone, T. (2008). Surgical treatment of endometriosis: a 7-year follow-up on the requirement for further surgery. Obstetrics & Gynecology, 111(6), 1285-1292. doi: 10.1097/AOG.0b013e3181758ec6
[16] Shcherbina, N A., Demidenko, D. I., & Demidenko, A. D. (2014). Токолитическая активность мелатонина при угрожающих преждевременных родах [Tocolytic activity of melatonin in threatening preterm labor]. Медицина неотложных состояний – Emergency medicine, 5(60), 100-102.
[17] Shestakova, I. G., & Ipastova, I. D. (2014). Эндометриоз: новый консенсус-новые решения. Глобальный консенсус по ведению больных эндометриозом как первый шаг к созданию отраслевых стандартов. Информационный бюллетень [Endometriosis: new consensus-new solutions. Global consensus on endometriosis management as a first step towards setting industry standards. Newsletter]. М.: Редакция журнала StatusPraesens – М.: Editorial office StatusPraesens.
[18] Singh, A. K., Chattopadhyay, R., Chakravarty, B., & Chaudhury, K. (2013). Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF. Reproductive toxicology, 42, 116-124. doi: 10.1016/j.reprotox.2013.08.005
[19] Tsoumpou, I., Kyrgiou, M., Gelbaya, T. A., & Nardo, L. G. (2009). The effect of surgical treatment for endometrioma on in vitro fertilization outcomes: a systematic review and meta-analysis. Fertility and sterility, 92(1), 75-87. doi: 10.1016/j.fertnstert.2008.05.049
[20] Tsysar, Yu. V., & Andriiets, O. A. (2011). Вплив патології щитоподібної залози на менструальну функцію у дівчат пубертатного віку [Influence of thyroid pathology on menstrual function in adolescent girls]. Буковинський медичний вісник – Bukovynian Medical Bulletin, 15(2), 130-134.
[21] Wang, X. T., Meng, B., Liu J. F., Jin, F. X., & Xu, H. (2018). The influences of ultrasound guided radiofrequency ablation assisted by polyol on fibroid volume and endocrine function among patients with uterine fibroid. Modern Practical Medicine, (30), 1425-1428.
[22] Yilmaz, B. D., & Bulun, S. E. (2019). Endometriosis and nuclear receptors. Human reproduction update, 25(4), 473-485. doi: 10.1093/humupd/dmz005
How to Cite
Kulyk, I. I., & Khmil , S. V. (2020). Features of the hormonal background of women with infertility on the background of endometriosis and methods of their correction. Biomedical and Biosocial Anthropology, (39), 57-61. https://doi.org/10.31393/bba39-2020-09