Antimicrobial activity of antiseptics in the prevention of postoperative infectious complications

  • N. A. Bagnyuk National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • O. A. Nazarchuk National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • Y. M. Babina National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • R. M. Chornopyshchuk National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • A. V. Kulyk National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Keywords: antiseptics, decamethoxin, chlorhexidine, polyhexanide.

Abstract

Recently, among hospital strains of microorganisms, an increase in the number of antiseptic-resistant strains of opportunistic pathogens has been registered, which significantly affects the effectiveness of these drugs. It is important to study their antimicrobial efficacy to justify rational use. The aim is to conduct a comparative study of the antimicrobial efficacy of antiseptics of decamethoxine, chlorhexidine, polyhexanide. During study we examined the antimicrobial activity against 186 clinical strains of microorganisms (Acinetobacter baumannii, Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus spp., Enterobacter spp.) isolated from patients with infectious complications in the postoperative period. The minimum inhibitory (MIC) and bactericidal concentrations (MBC) of 0.02 % and 0.1 % decamethoxine, 0.05 % chlorhexidine bigluconate, 0.1 % polyhexanide were determined; antimicrobial efficacy of drugs was evaluated by the index of antiseptic activity by conventional methods. The study found high antimicrobial properties of decamethoxine, chlorhexidine, which had a high bactericidal effect on clinical strains of S. aureus, Enterococcus spp., Enterobacter spp. Proved the benefits of antimicrobial activity of the drug based on decamethoxine (p<0.001). The polyhexanide has pronounced antimicrobial properties against A. baumannii, bacteria of the family Enterobactericae, P. aeruginosa. Thus, the leading gram-positive (Staphylococcus aureus, enterococci) and gram-negative pathogens (enterobacteria, acinetobacteria, pseudomonads) are sensitive to polyhexanide, chlorhexidine and the domestic drug decamethoxin, with a probable advantage of the antimicrobial properties of the latter over all gram-positive and most gram-negative microorganisms.

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Published
2021-11-27
How to Cite
Bagnyuk, N. A., Nazarchuk, O. A., Babina, Y. M., Chornopyshchuk, R. M., & Kulyk , A. V. (2021). Antimicrobial activity of antiseptics in the prevention of postoperative infectious complications. Biomedical and Biosocial Anthropology, (40), 33-36. https://doi.org/10.31393/bba40-2020-05