Features of the COPD course in patients with different alleles of C79G (rs1072714) of ADRB2 gene

  • Y. M. Mostovoy National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • K. D. Dmytriiev National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • N. S. Slepchenko National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Keywords: COPD, ADRB2, polymorphism, clinical course, exacerbation.


Chronic obstructive pulmonary disease (COPD) is a widely spread disease, that can be prevented and treated. As it was mentioned in the GOLD guidelines, genetic factors have a prominent impact on the development of COPD. A great amount of different genes is involved into the development of COPD. They influence processes of inflammation, fibrosis and regulation of airways reactivity. Polymorphism of ADRB2 gene is of a particular interest as it is associated with the development of COPD and response to beta-2 agonists, which are the main drugs used in the treatment of COPD. The aim of our study was to investigate an impact of the polymorphism of ADRB2 gene on the clinical course of COPD. We collected source data, medical history in all patients in order to assess smoking status and smoking experience, clinical group of COPD according to GOLD classification, total amount of exacerbations, exacerbations treated in in-patient and out-patient conditions, data about use of antibiotics, glucocorticosteroids and methylxanthines. Blood was collected in all patients for the genetic analysis of ADRB2 gene polymorphism. Among COPD patients 65 (65 %) had changes in ADRB2 gene. 26 patients (26 %) had mutation and 39 patients (39 %) had polymorphism of ADRB2 gene, which indicate possible relation of ADRB2 gene with the COPD development. Patients of group 1, C79C allele carriers, had milder COPD course, which presented with the significant difference in the of GOLD D patients in this group (17.14±7.13 %) and group 2, C79G allele carriers, (58.97±8.15 %) and group 3, G79G allele carriers, (34.61±9.59 %). Group 1 patients had lower amount of exacerbations (2.543±0.281) when compared to group 3 (2.963±0.273), and lower amount of hospital admissions (1.031±0.154) when compared to group 2 (1.332±0.167). Group 1 patients also used less antibiotics then other groups. So, ADRB2 gene polymorphism in C79G positions is a prognostic factor of the severity of COPD course. It is associated with the greater amount of exacerbations and hospitalizations and also greater antibiotic use.


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How to Cite
Mostovoy, Y. M., Dmytriiev, K. D., & Slepchenko, N. S. (2021). Features of the COPD course in patients with different alleles of C79G (rs1072714) of ADRB2 gene. Biomedical and Biosocial Anthropology, (42), 39-43. https://doi.org/10.31393/bba42-2021-07

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