Perspectives of cell technologies in experimental degenerative disc disease
This work presents a review of the results of the effectiveness of cell therapy in experimental osteochondrosis of native and foreign scientists in the last decade. The review of the developed strategies of the experimental treatment of degenerative disc disease with the use of mesenchymal stem cells, as well as different ways of their introduction into the damaged tissue, is represented. Although, there is a data about the applying of different methods of injection of mesenchymal stem cells, the question about the most effective one remains unexplored. A popular up-to-date kind of cell therapy platelet-rich plasma (PRP) is also mentioned. The examples of effective therapy of experimental osteoarthritis using PRP injection form and the form of hydrogel microchips are shown. Related to the decreased activity of mesenchymal stem cells and their number in the patient's body with age of sickness issues are mentioned. The use of cell therapy in the treatment of degenerative disc disease is a promising method, but it requires the solution of a number of important issues related to the transplantation of mesenchymal stem cells before being introduced into clinic.