Violation of the livertissue energy supply as a way of alimentary obesity


  • O. P. Myalyuk
  • I. M. Klishch
  • V. V. Zaets
  • M. I. Marushchak
Keywords: experimental obesity, succinate dehydrogenase, cytochrome oxidase

Abstract

In the article it was studied nutritional state of the electron transport chain of the liver mitochondria on the experimental models of obesity. It was found the tendency to decline in the cells energy supply after 14 days of experiment, whereas after 28 days it was the significant decrease of succinate dehydrogenase activity (17,1 %) and cytochrome oxidase activity (25,6%) in the liver tissue (p<005). The direct positive relationship between the activity of succinate dehydrogenase and zinc content in the liver tissue, as well as the neagtive link between copper and cytochrome oxidase it was found (p<0,05). So, on the basis of these data we can assert with a certain probability that the negative impact on the functioning of the citric acid cycle in the alimentary obesity has copper, because cytochrome oxidase activity decreases with increasing of copper content in the liver tissue (rxy = (-0,65), p<0,05). Lower zinc content in the liver does not have a positive influence on the cell energy activation.

Published
2017-03-31
How to Cite
Myalyuk, O. P., Klishch, I. M., Zaets, V. V., & Marushchak, M. I. (2017). Violation of the livertissue energy supply as a way of alimentary obesity. Biomedical and Biosocial Anthropology, (25), 23-26. Retrieved from https://bba-journal.com/index.php/journal/article/view/67