Impact of infusion therapy on structural changes in rat adenohypophysis in experimental dermal burn injury
The paper presents data related to the autophagy and crinophagy in rat adenohypophysis in treatment of burn injury by the infusion of lactoprotein with sorbitol and HAES-LX-5%. It has been established that intravenous infusion of lactoproteinum with sorbitol in rat experimental burn disease leads to structural transformations of histohematic barrier when interaction of vascular wall cells and endocrine cells enables the formation of "collateralized membrane complex" in the adenohypophysis. Administration of lactoprotein with sorbitol andHAES-LX-5% inhibits structural manifestations of cell death andensures thelife saving of adenohypophysis endocrine cells by involvement of mechanisms for autophagy and сrinophagy. Crinophagy of endocrine cells in the adenohypophysis is adaptivein nature; it ensures elimination and disposal of excess hormones, distorted as a resultof catabolic reaction, specific for burn disease. Autophagy is activated in case of urgent (emergency) need to extrude the damaged organellestogether with adjacent areas of cytoplasm.