Behavioral responses as biomarkers of neurotoxicity inhygienicst and ardization of polymer materials
The effect of the plasticizer dibutyl phthalate (DBP), a flame retardant hexabromocyclododecane (HBCD) and their combination on behavioral reaction of laboratory animals (white rats) studied in the chronic experiment. To assess the functional state of the nervous system the tests "Cruciform labyrinth" and "Open field" are used. Statistically significant differences (p<0,05) were found in the motor, emotional and cognitive activity changes in isolated and combined experiments of the investigated components of polymeric materials. The greatest toxicity at the early stages of the expositions' (4 weeks) showed DBP. The combined effects of the identified changes were more marked in the later stages of the experiment. The effects observed in the emotional sphere developed by the type of summation, and cognitive - potentiation. This probably reflects the expression of the time-based effects associated with the development of the delayed impact with dominant role belongs to the endocrine disruptor HBCD. It is concluded that the behavioral patterns of toxicity are informative and sensitive biomarkers in new polymers and their chemical components standardization.