Generalized seizure activity in conditions of interleukin-1- beta receptors blockade


  • R. S. Vastyanov
  • Yu. S. Strelnikova
Keywords: interleukin-1-beta, recombinant interleukin-1 antagonist, acute generalized seizures, GABA-ergic system, cholinergic system, immune system, pathogenesis

Abstract

The data revealed the acute generalized seizure activity induced by convulsive agents with different mechanisms of convulsive action realization due to interleukin-1-beta receptors blockade by recombinant antagonist of interleukin-1-beta (RAIL) use. RAIL dose-dependent efficacy was shown in conditions of both picrotoxin- and pentylenetetrazol-induced seizures characterized by seizure reactions intensity reduction, the numbers of animals with generalized clonic-tonic seizures decreased and the first seizures latency increase. Acute pilocaprine-, strychnine- and kainic-induced seizures latency also prolonged in case of RAIL maximal dose injection. Strychnine-induced seizures intensity significantly decreases in the same conditions. Authors concluded about immune system involvement into acute generalized seizure activity induced mainly by GABA- and cholinergic neurotransmitter systems activity dysbalance as well as about the principal possibility of antiepileptic effect development due to interleukin-1 receptors blockade.

Published
2017-03-31
How to Cite
Vastyanov, R. S., & Strelnikova, Y. S. (2017). Generalized seizure activity in conditions of interleukin-1- beta receptors blockade. Biomedical and Biosocial Anthropology, (25), 76-81. Retrieved from https://bba-journal.com/index.php/journal/article/view/80