Generalized seizure activity in conditions of interleukin-1- beta receptors blockade
The data revealed the acute generalized seizure activity induced by convulsive agents with different mechanisms of convulsive action realization due to interleukin-1-beta receptors blockade by recombinant antagonist of interleukin-1-beta (RAIL) use. RAIL dose-dependent efficacy was shown in conditions of both picrotoxin- and pentylenetetrazol-induced seizures characterized by seizure reactions intensity reduction, the numbers of animals with generalized clonic-tonic seizures decreased and the first seizures latency increase. Acute pilocaprine-, strychnine- and kainic-induced seizures latency also prolonged in case of RAIL maximal dose injection. Strychnine-induced seizures intensity significantly decreases in the same conditions. Authors concluded about immune system involvement into acute generalized seizure activity induced mainly by GABA- and cholinergic neurotransmitter systems activity dysbalance as well as about the principal possibility of antiepileptic effect development due to interleukin-1 receptors blockade.