Official Journal of the International Academy of Integrative Anthropology
DOI: 10.31393
ISSN 1861-031Х
eISSN 2616-6208
Biomedical and Biosocial
Аnthropology
41, 2020
Scientific peer-reviewed journal in the fields of medicine, biology, anthropology, ecology,
health care organizations, medical economics
Published since 2003
Periodicity: 4 times a year
Aleksandrów Łódzki 2020
ORIGINAL ARTICLES
ORIGINAL ARTICLES
Biomedical and Biosocial Anthropology
Founders: Public organization "International Academy of Integrative Anthropology", Polish
representation of the Public Organization "International Academy of Integrative Anthropology" and
National Pirogov Memorial Medical University, Vinnytsya
Registered on 09.21.2020 in the ISSN Registration Department of the People's Library, Warsaw,
Poland
Chairman of the editorial board - Moroz V.M. (Ukraine)
Vice-Chairman of Editorial Board: Ks. Stasiak Jacek (Poland); Soboń Janusz (Poland)
Responsible editor - Gunas I.V. (Ukraine)
Secretary - Seleznyova Ruslana (Poland)
Editorial Board Members:
Adarsh Kumar (India); Byard Roger (Germany); Bornstein Natan (Israel); Dgebuadze Maia (Georgia);
Janiszewski Mirosław (Poland); Juenemann Anselm (Germany); Graeb Christian (Germany); Gulmen
Mete Korkut (Turkey); Rejdak Robert (Poland); Rogozińska-Mitrut Joanna (Poland); Maievskyi
Oleksandr, (Ukraine); Sarafinyuk Larisa (Ukraine); Serheta Igor (Ukraine)
Editorial council:
Bulyk R.Ye. (Ukraine); Chaikovsky Yu.B. (Ukraine); Dmytrenko S.V. (Ukraine); Furman Yu.M. (Ukraine);
Guminskiy Yu.Y. (Ukraine); Gzhegotskyi M.R. (Ukraine); Mateshuk-Vatseba L.R. (Ukraine);
Mishalov V.D. (Ukraine); Mostoviy Yu.M. (Ukraine); Pogoriliy V.V. (Ukraine); Prokopenko S.V. (Ukraine);
Puchlik B.M. (Israel); Shepitko V.I. (Ukraine); Shkolnikov V.S. (Ukraine); Shutz Yu. (Germany); Vasylenko
D.A. (Ukraine); Włodzimierz Ziółkowski (Poland); Yoltukhivskyy M.V. (Ukraine)
Approved by the editorial board of the journal "Biomedical and Biosocial Anthropology", protocol
№4 from 25.12.2020
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Levenchuk S.S., Parashuk O.I.
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CONTENT
4
Volotovska N. V. Study of morphological changes in the kidney during modeling of ischemic-reperfusion
injuries of the limb and massive blood loss ......................................................................................................... 5
Ivankova A. V., Kuzminova N. V., Lozinsky S. E., Ivanov V. P. Comparative assessment of renal function
by cystatin C level in patients with hypertension and extrasystole ................................................................... 11
Drachevska I. Yu., Dmitriev М. О., Perera Clifford, Shevchenko V. M., Gunas I. V. Determination of
cephalometric parameters, which usually do not change during surgical and orthodontic treatment
depending on facial types according to Garson in Ukrainian young men and young women with
orthognathic occlusion ...................................................................................................................................... 18
Grebeniuk D. I., Voloshchuk N. I., Taran I. V., Gormash P. P., Nazarchuk O. A. Evaluation of the effect
of excess and deficiency of serum hydrogen sulfide on the condition of the vaginal wall of intact rats .............. 24
Halushka A. M., Khalik S. V., Rychka O. V., Lopin Ye. B. Actual aspects of traumatic pathology among
servicemen of Ukrainіan Armed Forces in Joint Forces Operation .................................................................... 30
Malchenko O. V., Voloschuk N. I., Pentiuk N. O. Investigation of 4-methyl-2.2-dioxo-1h-2λ
6
,1-benzothiazine-
3-carboxamide derivative influence on the biochemical markers of gastric mucosa in rats ............................... 36
Samborska I. A. Changes in the histostructure of the lungs of old rats under conditions of persistent
hyperhomocysteinemia ..................................................................................................................................... 41
Bondarenko P. S., Voloshchuk N. I., Larionov V. B., Fedoseenko H. О. Investigation of
pharmacokinetics of N-(4-trifluoromethylphenyl)-4-methyl-2.2-dioxo-1H-2λ6.1-benzothiazine-3-carboxamide
various crystalline modifications in vivo ............................................................................................................. 46
Vakhovskyi V. V., Shinkaruk-Dykovytska М. М., Pogorila A. V., Likhitskyi O. O., Gunas I. V.
Correlations of basal cranial structures characteristics determined by Bjork and Jarabak methods with
teleradiographic parameters of the upper and lower jaws and tooth location in young men and young
women with orthognathic occlusion .................................................................................................................. 52
Khasawneh Ahmad Raed, Dmytrenko S. V., Kizina I. E., Kyrychenko Yu. V., Prokopenko S. V.
Correlations between the severity of oily skin and the emotional impact of oily skin with
anthropo-somatotypological parameters of men and women with seborrheic dermatitis ................................... 60
Study of morphological changes in the kidney during modeling of
ischemic-reperfusion injuries of the limb and massive blood loss
Volotovska N. V.
I. Ya. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
The article presents the features of morphological disorders of liver tissue on the
background of limb ischemia-reperfusion and massive blood loss. The aim of the work
was to establish the presence of structural changes and the severity of morphological
disorders of internal organs, remote from the primary place of ischemia-reperfusion
during modeling the pathological process. The experiment was performed on 33 adult
nonlinear white rats weighing 200-250 g, which were on the standard vivarium diet.
Experimental animals were simulated with ischemic-reperfusion syndrome of the lower
extremity and massive blood loss. Collection of materials was performed 1 h after
intervention or release from the tourniquet and on the 1st, 3rd, 7th and 14th days. All
interventions were performed under thiopental-sodium anesthesia (40 mg/kg body
weight). Mostly structural violations were expressed as disturbance of blood supply of
little and middle caliber blood vessels and also in initial dystrophic changes. During
comparison of groups, depending on the severity, it was shown that both the isolated
use of a tourniquet and massive blood loss had long-term, systemic consequences,
however, more expressed in EG-2; single vascular glomeruli were shrunked, endothelial
cells of arterioles were slightly damaged. On the 7th and 14th days changes in the
structure of EG-1 were mostly absent, although in EG-2 the epitheliocytes of the outer
layer of the capsule remained flattened, retained full blood vessels of the venous bed
in the interstitium, and the vast majority of epitheliocytes of the excretory tubules were
at different stages of hydropic dystrophy with partly desquamation of the epithelium in
the gaps of the tubules. Also, the basal membranes of the tubules were not completely
visualized, which indicates deep damage in the structures caused by acute ischemia
as a result of bleeding. Thus, as combat trauma (blood loss) is in itself a life-threatening
factor, the use of a tourniquet due to the development of ischemic-reperfusion process
can complicate the course of the primary affection. Knowledge of the periodization of
traumatic disease on the background of this pathology is important for the development
of sanogenic effects in order to minimize this pathogenic factor.
Key words: hemostatic tourniquet, kidney, experiment, ischemic-reperfusion syndrome,
blood loss).
ARTICLE INFO
Received: 21 October 2020
Accepted: 24 November 2020
UDC: 616.61:616.748-005.1/.4]-092.9
CORRESPONDING AUTHOR
e-mail: volotovskanv@tdmu.edu.ua
Volotovska N. V.
© 2020 Medical centre "Gebrand", Poland
5
DOI: 10.31393/bba41-2020-01 Biomedical and Biosocial Anthropology, №41, Pages 5-10
ISSN 1861-031Х eISSN 2616-6208
BIOMEDICAL AND BIOSOCIAL ANTHROPOLOGY
Official Journal of the International Academy
of Integrative Anthropology
journal homepage: http://bba-journal.com
Introduction
The use of a tourniquet is still an important first aid
measure [11, 13]. Active battles that occur periodically in
the modern world, including in Ukraine, are accompanied
with injuries and blood loss and require careful study of
the mechanisms of posttraumatic period. A significant role
of ischemic-reperfusion syndrome due to the use of
tourniquet now is actively discussed [1, 9]. There are
materials in the literature that highlight the ambiguity of
reperfusion changes as a result use of a tourniquet.
The pathogenesis of the process is based not only on
hemic hypoxia, but also on the combination of its
consequences with manifestations of rhabdomyolysis and
massive entry into the systemic bloodstream of products
of lipid and protein peroxidation from exsanguinated tissues
[4]. The morphological changes of skeletal muscles that
were under pressure of the tourniquet were best studied
[18]; they consisted of dystrophic changes in muscle fibers
and were apparently caused by a violation of ionic
composition, an imbalance of metabolic processes due to
a shift in acid-base balance on the background of tissue
hypoxia. In particular, the structural changes of the soft
tissues of the extremities and modifications in the